It also called as Protease or proteinase that performs proteolysis. Major sources of proteases are animal, plant and microbial including fungi and bacteria. Protease conducts proteolysis, that is, begins protein catabolism by hydrolysis of the peptide bonds that link amino acids together in the polypeptide chain forming the protein. Proteases are a unique class of enzymes as they possess both degradative and synthetic properties. They is widely used as detergent, in food, pharmaceutical and leather tanning industries.